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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/Nepicastat hydrochloride/5037/50/50 mg
产品编号:5037/50
市  场 价:¥13300.00
场      地:美国(厂家直采)
产品分类: 蛋白类>>其它酶>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$665.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/Nepicastat hydrochloride/5037/50/50 mg
商品介绍
Description:Potentandselectivedopamineβ-hydroxylase(DBH)inhibitor;orallybioavailable
ChemicalName:5-(Aminomethyl)-1-[(2S)-5,7-difluoro-1,2,3,4-tetrahydro-2-naphthalenyl]-1,3-dihydro-2H-imidazole-2-thionehydrochloride
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potentandselectivedopamineβ-hydroxylase(DBH)inhibitor(IC50=9nM).SelectiveforDBHover12otherenzymes.Decreasesnoradrenalineandincreasesdopaminelevelsintissuesandplasmainhypertensiverats.Preventsprogressiveleftventriculardysfunctioninaninvivoheartfailuremodel.Alsopotentiatesthestimuluseffectsofcocainewithoutproducingcocaine-likeeffectsinrats.Orallybioavailable.

TechnicalData

M.Wt331.81
FormulaC14H15F2N3S.HCl
StorageStoreat-20°C
Purity≥98%(HPLC)
CASNumber170151-24-3
PubChemID9840545
InChIKeyDIPDUAJWNBEVOY-PPHPATTJSA-N
SmilesS=C(NC=C3CN)N3[C@H]2CCC1=C(F)C=C(F)C=C1C2.Cl

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO33.18100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight331.81.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM3.01mL15.07mL30.14mL
5mM0.6mL3.01mL6.03mL
10mM0.3mL1.51mL3.01mL
50mM0.06mL0.3mL0.6mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet