Necroptosisinhibitor.Blocksmixedlineagekinasedomain-likeprotein(MLKL),acriticalsubstrateofreceptor-interactingserine-threoninekinase3(RIP3)duringnecrosis.PreventsMLKL-RIP1-RIP3necrosomecomplexfrominteractingwithdownstreamnecrosiseffectors.
M.Wt | 461.47 |
Formula | C18H15N5O6S2 |
Storage | Storeat+4°C |
Purity | ≥98%(HPLC) |
CASNumber | 1360614-48-7 |
PubChemID | 1566236 |
InChIKey | FNPPHVLYVGMZMZ-XBXARRHUSA-N |
Smiles | O=C(NC2=CC=C(S(NC3=C(OC)N=CC=N3)(=O)=O)C=C2)/C=C/C1=CC=C([N+]([O-])=O)S1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 9.23 | 20 |
Thefollowingdataisbasedontheproductmolecularweight461.47.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.17mL | 10.83mL | 21.67mL |
5mM | 0.43mL | 2.17mL | 4.33mL |
10mM | 0.22mL | 1.08mL | 2.17mL |
50mM | 0.04mL | 0.22mL | 0.43mL |