Necroptosisinhibitor.Blocksmixedlineagekinasedomain-likeprotein(MLKL),acriticalsubstrateofreceptor-interactingserine-threoninekinase3(RIP3)duringnecrosis.PreventsMLKL-RIP1-RIP3necrosomecomplexfrominteractingwithdownstreamnecrosiseffectors.
| M.Wt | 461.47 |
| Formula | C18H15N5O6S2 |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1360614-48-7 |
| PubChemID | 1566236 |
| InChIKey | FNPPHVLYVGMZMZ-XBXARRHUSA-N |
| Smiles | O=C(NC2=CC=C(S(NC3=C(OC)N=CC=N3)(=O)=O)C=C2)/C=C/C1=CC=C([N+]([O-])=O)S1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 9.23 | 20 |
Thefollowingdataisbasedontheproductmolecularweight461.47.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.17mL | 10.83mL | 21.67mL |
| 5mM | 0.43mL | 2.17mL | 4.33mL |
| 10mM | 0.22mL | 1.08mL | 2.17mL |
| 50mM | 0.04mL | 0.22mL | 0.43mL |



