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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/Narciclasine/3715/1/1 mg
产品编号:3715/1
市  场 价:¥3300.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$165.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/Narciclasine/3715/1/1 mg
商品介绍
Description:Antiproliferativeagent;slowscellcycleprogression
ChemicalName:(2S,3R,4S,4aR)-3,4,4a,5-Tetrahydro-2,3,4,7-tetrahydroxy-(1,3)dioxolo(4,5-j)phenanthridin-6(2H)-one
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Exhibitsantiproliferativeandpro-apoptoticeffectsincarcinomacellsanddisplayscytotoxicactivityagainstapanelof60cancercelllines(meanIC50=47nM).Activitydecreasesrateofcelldivisionandincreasesmitosisdurationinvitro.AlsomodulatestheRho/ROCK/LIMkinase/cofilinpathway;stimulatesRhoAactivationandinducesactinpolymerization.

TechnicalData

M.Wt307.26
FormulaC14H13NO7
StorageStoreat-20°C
Purity≥98%(HPLC)
CASNumber29477-83-6
PubChemID72376
InChIKeyLZAZURSABQIKGB-AEKGRLRDSA-N
SmilesOC1=C(C(N[C@]4([H])C3=C[C@H](O)[C@@H](O)[C@H]4O)=O)C3=CC2=C1OCO2

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO30.73100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight307.26.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM3.25mL16.27mL32.55mL
5mM0.65mL3.25mL6.51mL
10mM0.33mL1.63mL3.25mL
50mM0.07mL0.33mL0.65mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet