Exhibitsantiproliferativeandpro-apoptoticeffectsincarcinomacellsanddisplayscytotoxicactivityagainstapanelof60cancercelllines(meanIC50=47nM).Activitydecreasesrateofcelldivisionandincreasesmitosisdurationinvitro.AlsomodulatestheRho/ROCK/LIMkinase/cofilinpathway;stimulatesRhoAactivationandinducesactinpolymerization.
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Thefollowingdataisbasedontheproductmolecularweight307.26.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.