MDM2antagonist(IC50=90nM);inhibitstheMDM2-p53interaction.ActiveenantiomerofNutlin-3(Cat.No.3984).InducesexpressionforP53regulatedgenes.Suppressestumorgrowthinvivo>98%inprostatecancerandosteosarcomacancermodels.Antiproliferative.
| M.Wt | 581.49 |
| Formula | C30H30Cl2N4O4 |
| Storage | Storeat-20°C |
| Purity | ≥97%(HPLC) |
| CASNumber | 675576-98-4 |
| PubChemID | 11433190 |
| InChIKey | BDUHCSBCVGXTJM-WUFINQPMSA-N |
| Smiles | ClC1=CC=C([C@H]2[C@H](N(C(N3CC(NCC3)=O)=O)C(C4=CC=C(OC)C=C4OC(C)C)=N2)C5=CC=C(Cl)C=C5)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 58.15 | 100 | |
| ethanol | 58.15 | 100 |
Thefollowingdataisbasedontheproductmolecularweight581.49.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.72mL | 8.6mL | 17.2mL |
| 5mM | 0.34mL | 1.72mL | 3.44mL |
| 10mM | 0.17mL | 0.86mL | 1.72mL |
| 50mM | 0.03mL | 0.17mL | 0.34mL |



