Wntsignalinginhibitor.BindsthePDZdomainoftheDishevelled(Dvl)protein.Inhibitsproliferation,migrationandTGF-β-induceddifferentiationoffibroblastsinvitro.Reducesseverityofpulmonaryfibrosisinamousemodel.
M.Wt | 460.52 |
Formula | C21H36N2O9 |
Storage | Storeat-20°C |
Purity | ≥98%(HPLC) |
CASNumber | 144678-63-7 |
PubChemID | 71312060 |
InChIKey | IPICFSFUAKDZEI-AJNGGQMLSA-N |
Smiles | CC([C@@H](C(O)=O)OC([C@@H](NC([C@H](C(C)C)OC([C@@H](NC(OC(C)(C)C)=O)C)=O)=O)C)=O)C |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 46.05 | 100 | |
ethanol | 46.05 | 100 |
Thefollowingdataisbasedontheproductmolecularweight460.52.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.17mL | 10.86mL | 21.71mL |
5mM | 0.43mL | 2.17mL | 4.34mL |
10mM | 0.22mL | 1.09mL | 2.17mL |
50mM | 0.04mL | 0.22mL | 0.43mL |