KDM4A/KDM4Binhibitor;inhibitshistonedemethylaseactivityonH3K9me3andinducesapoptosisinLNCaPprostatecancercellsinvitro.Alsonegativelyregulatesandrogen-responsivegenes.
| M.Wt | 510.15 |
| Formula | C22H12Cl4N2O4 |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1618672-71-1 |
| PubChemID | 6288112 |
| InChIKey | YYZPXBXVBQSBDG-IJIVKGSJSA-N |
| Smiles | ClC(C=C1)=C(Cl)C=C1/C=C/C2=C([N+]([O-])=O)C=C([N+]([O-])=O)C(/C=C/C3=CC=C(Cl)C(Cl)=C3)=C2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 5.1 | 10 |
Thefollowingdataisbasedontheproductmolecularweight510.15.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.96mL | 9.8mL | 19.6mL |
| 5mM | 0.39mL | 1.96mL | 3.92mL |
| 10mM | 0.2mL | 0.98mL | 1.96mL |
| 50mM | 0.04mL | 0.2mL | 0.39mL |



