Wernersyndromehelicase(WRN)helicaseinhibitor(IC50=250nM);actssynergisticallywithMitomycinC(Cat.No.3258)toinducedouble-strandbreaksandchromosomalabnormalitiesinvitro.
| M.Wt | 400.04 |
| Formula | C13H10Cl4N2O4 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 203115-63-3 |
| PubChemID | 357621 |
| InChIKey | PCOXPBOKDABARQ-UHFFFAOYSA-N |
| Smiles | CC(CN1C(C(Cl)=C(Cl)C1=O)=O)(C)CN2C(C(Cl)=C(Cl)C2=O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 8 | 20 |
Thefollowingdataisbasedontheproductmolecularweight400.04.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.5mL | 12.5mL | 25mL |
| 5mM | 0.5mL | 2.5mL | 5mL |
| 10mM | 0.25mL | 1.25mL | 2.5mL |
| 50mM | 0.05mL | 0.25mL | 0.5mL |



