Reactivatorofmutantp53.Restoreswildtypep53structureandfunctiontothep53R175mutant.Inhibitsgrowthoffibroblastsexpressingthep53R175mutation(IC50=8nM).Alsoinhibitsgrowthofxenografttumorsexpressingthep53R175mutationinvivo.
NSC319726isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 234.32 |
Formula | C11H14N4S |
Storage | Storeat-20°C |
Purity | ≥98%(HPLC) |
CASNumber | 71555-25-4 |
PubChemID | 5351307 |
InChIKey | XDHBUMNIQRLHGO-UKTHLTGXSA-N |
Smiles | C/C(C1=NC=CC=C1)=NNC(N2CCC2)=S |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 23.43 | 100 | |
ethanol | 2.34 | 10mMwithgentlewarming |
Thefollowingdataisbasedontheproductmolecularweight234.32.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 4.27mL | 21.34mL | 42.68mL |
5mM | 0.85mL | 4.27mL | 8.54mL |
10mM | 0.43mL | 2.13mL | 4.27mL |
50mM | 0.09mL | 0.43mL | 0.85mL |