Cell-permeable,genotype-selectiveantitumoragentthatactivatesp53-dependenttranscription.Increaseslevelsofendogenousp53intumorcellsandprotectsp53fromMdm2-mediateddegradation.Displayssomeselectivityfortumorcellsvs.normalcellsinanMTTcellviABIlityassay.
M.Wt | 316.85 |
Formula | C17H16N2S.HCl |
Storage | DesiccateatRT |
Purity | ≥99%(HPLC) |
CASNumber | 59474-01-0 |
PubChemID | 5458312 |
InChIKey | VIBMUYOXJUCEMA-UHFFFAOYSA-N |
Smiles | N=C(N)SCC1=C(C=CC=C3)C3=C(C)C2=C1C=CC=C2.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 31.68 | 100 | |
ethanol | 3.17 | 10 |
Thefollowingdataisbasedontheproductmolecularweight316.85.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 3.16mL | 15.78mL | 31.56mL |
5mM | 0.63mL | 3.16mL | 6.31mL |
10mM | 0.32mL | 1.58mL | 3.16mL |
50mM | 0.06mL | 0.32mL | 0.63mL |