SelectiveCD45inhibitor(IC50=200nM).Exhibits>200-foldselectivityforCD45oversixrelatedproteintyrosinephosphatases.IncreasesphosphorylationofLckinJurkatcellsandreducesTcellreceptorsignalinginacitvatedsplenocytesinvitro.Blocksinflammationinadelayed-typehypersensitivitymodelinvivo.
M.Wt | 325.75 |
Formula | C18H12ClNO3 |
Storage | Storeat-20°C |
Purity | ≥98%(HPLC) |
CASNumber | 130089-98-4 |
PubChemID | 781109 |
InChIKey | LSQZKIQSQHZVQS-UHFFFAOYSA-N |
Smiles | O=C1C(Cl)=C(NC2=CC=C(C(C)=O)C=C2)C(C3=CC=CC=C31)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 32.58 | 100 |
Thefollowingdataisbasedontheproductmolecularweight325.75.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 3.07mL | 15.35mL | 30.7mL |
5mM | 0.61mL | 3.07mL | 6.14mL |
10mM | 0.31mL | 1.53mL | 3.07mL |
50mM | 0.06mL | 0.31mL | 0.61mL |