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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/NPS 2143 hydrochloride/3626/50/50 mg
产品编号:3626/50
市  场 价:¥15300.00
场      地:美国(厂家直采)
产品分类: 生化试剂>生物分子>受体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$765.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/NPS 2143 hydrochloride/3626/50/50 mg
商品介绍
Description:SelectiveantagoNISTofthecalcium-sensingreceptor;orallyactivecalcilyticagent
ChemicalName:2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino-2-hydroxypropoxy]benzonitrilehydrochloride
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

SelectiveCa2+-sensingreceptorantagonist.BlocksincreasesincytoplasmicCa2+concentrationselicitedbyhumanCa2+receptorsexpressedinHEK293cells(IC50=43nM).Alsostimulatesparathyroidhormonesecretionfrombovineparathyroidcells(EC50=41nM).Orallyactivecalcilyticcompound.

CompoundLibraries

NPS2143hydrochlorideisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt445.38
FormulaC24H25ClNO2.HCl
StorageDesiccateatRT
Purity≥99%(HPLC)
CASNumber324523-20-8
PubChemID9868131
InChIKeyZEBNDUQLNGYBNL-VEIFNGETSA-N
SmilesCC(NC[C@@H](O)COC3=C(C#N)C(Cl)=CC=C3)(C)CC2=CC1=CC=CC=C1C=C2.Cl

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO44.54100
ethanol4.4510

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight445.38.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.25mL11.23mL22.45mL
5mM0.45mL2.25mL4.49mL
10mM0.22mL1.12mL2.25mL
50mM0.04mL0.22mL0.45mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet