Water-solubleanalogofforskolin(Cat.No.1099)thatisapotentactivatorofadenylylcyclase;showssomeselectivityforcardiac(typeV)adenylylcyclase.Stimulatesbronchodilation(EC50=32.6nM)andisanorallyactivepotentpositivechronotropeandhypotensiveagentinvivo.AlsoavailableaspartofthePKATocriset™.
M.Wt | 546.1 |
Formula | C27H43NO8.HCl |
Storage | Desiccateat+4°C |
Purity | ≥98%(HPLC) |
CASNumber | 138605-00-2 |
PubChemID | 444028 |
InChIKey | VIRRLEDAYYYTOD-YHEOSNBFSA-N |
Smiles | O=C(CCN(C)C)O[C@H]2[C@@]1([H])C(C)(C)CC[C@H](O)[C@@](C)1[C@]3(O)[C@@](O[C@](C=C)(C)CC3=O)(C)[C@H]2OC(C)=O.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 54.61 | 100 | |
ethanol | 8.19 | 15 | |
water | 21.84 | 40 |
Thefollowingdataisbasedontheproductmolecularweight546.1.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 1.83mL | 9.16mL | 18.31mL |
5mM | 0.37mL | 1.83mL | 3.66mL |
10mM | 0.18mL | 0.92mL | 1.83mL |
50mM | 0.04mL | 0.18mL | 0.37mL |