PotentandselectiveEBI2(GPR183)receptorantagonist(IC50valuesare11and15nMforhumanandmouseEBI2receptorsrespectively).ExhibitsselectivityforEBI2overapanelofotherreceptors,enzymesandtransporters.Blocksoxysterol-inducedmigrationofU937monocytecells.Orallybioavailable.
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Thefollowingdataisbasedontheproductmolecularweight429.31.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.