PotentandselectiveEBI2(GPR183)receptorantagonist(IC50valuesare11and15nMforhumanandmouseEBI2receptorsrespectively).ExhibitsselectivityforEBI2overapanelofotherreceptors,enzymesandtransporters.Blocksoxysterol-inducedmigrationofU937monocytecells.Orallybioavailable.
M.Wt | 429.31 |
Formula | C21H21BrN2O3 |
Storage | Storeat+4°C |
Purity | ≥99%(HPLC) |
CASNumber | 1599432-08-2 |
PubChemID | 36295259 |
InChIKey | OFHXXBRBGWUOHR-NYYWCZLTSA-N |
Smiles | BrC1=CC=C(/C=C/C(N2CCN(C(C3=CC=C(OC)C=C3)=O)CC2)=O)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 42.93 | 100 |
Thefollowingdataisbasedontheproductmolecularweight429.31.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.33mL | 11.65mL | 23.29mL |
5mM | 0.47mL | 2.33mL | 4.66mL |
10mM | 0.23mL | 1.16mL | 2.33mL |
50mM | 0.05mL | 0.23mL | 0.47mL |