PotentandselectiveEBI2(GPR183)receptorantagonist(IC50valuesare11and15nMforhumanandmouseEBI2receptorsrespectively).ExhibitsselectivityforEBI2overapanelofotherreceptors,enzymesandtransporters.Blocksoxysterol-inducedmigrationofU937monocytecells.Orallybioavailable.
| M.Wt | 429.31 |
| Formula | C21H21BrN2O3 |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 1599432-08-2 |
| PubChemID | 36295259 |
| InChIKey | OFHXXBRBGWUOHR-NYYWCZLTSA-N |
| Smiles | BrC1=CC=C(/C=C/C(N2CCN(C(C3=CC=C(OC)C=C3)=O)CC2)=O)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 42.93 | 100 |
Thefollowingdataisbasedontheproductmolecularweight429.31.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.33mL | 11.65mL | 23.29mL |
| 5mM | 0.47mL | 2.33mL | 4.66mL |
| 10mM | 0.23mL | 1.16mL | 2.33mL |
| 50mM | 0.05mL | 0.23mL | 0.47mL |



