Potentandselectiveσ1receptorantagonist(Ki=0.86nM)thatdisplays>55-foldselectivityoverσ2receptorsand>6000-foldselectivityoverD1,D2,5-HT1A,5-HT2andPCPreceptors.ExhibitsreversIBLebinding(Kd=1.2nM)anddisplaysantipsychoticactivityinvivo.Orallyactive.
NE100hydrochlorideisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 391.97 |
Formula | C23H33NO2.HCl |
Storage | Storeat-20°C |
Purity | ≥98%(HPLC) |
CASNumber | 149409-57-4 |
PubChemID | 9952420 |
InChIKey | ZHGMDXSHODHWHV-UHFFFAOYSA-N |
Smiles | CCCN(CCC)CCC1=CC=C(OC)C(OCCC2=CC=CC=C2)=C1.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 39.2 | 100 | |
water | 9.8 | 25 |
Thefollowingdataisbasedontheproductmolecularweight391.97.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.55mL | 12.76mL | 25.51mL |
5mM | 0.51mL | 2.55mL | 5.1mL |
10mM | 0.26mL | 1.28mL | 2.55mL |
50mM | 0.05mL | 0.26mL | 0.51mL |