请使用支持JavaScript的浏览器!
主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/NDT 9513727/3333/50/50 mg
产品编号:3333/50
市  场 价:¥20900.00
场      地:美国(厂家直采)
产品分类: 生化试剂>其他>其他试剂>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$1045.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/NDT 9513727/3333/50/50 mg
商品介绍
Description:Potent,selectivehumanC5areceptorantagoNIST
ChemicalName:N,N-Bis(1,3-benzodioxol-5-ylmethyl)-1-butyl-2,4-diphenyl-1H-Imidazole-5-methanamine
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentC5areceptor(C5aR)competitiveantagonist(IC50=11.6nM);selectiveforhumanC5aR(IC50valuesforratandmouseC5aRare>10μM).Exhibitsinverseagonistpharmacokinetics.BlocksdegranulationresponseinC5a-stimulatedU937cells(IC50=7.1nM).Orallybioavailable.

CompoundLibraries

NDT9513727isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt573.68
FormulaC36H35N3O4
StorageStoreat+4°C
Purity≥98%(HPLC)
CASNumber439571-48-9
PubChemID10210160
InChIKeyITACCRHKSPSKKL-UHFFFAOYSA-N
SmilesCCCCN1C(C6=CC=CC=C6)=NC(C7=CC=CC=C7)=C1CN(CC3=CC(OCO5)=C5C=C3)CC2=CC=C(OCO4)C4=C2

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO57.37100
ethanol57.37100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight573.68.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM1.74mL8.72mL17.43mL
5mM0.35mL1.74mL3.49mL
10mM0.17mL0.87mL1.74mL
50mM0.03mL0.17mL0.35mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet