CD4mimetic(IC50valuesareinlowmicromolarrange,dependentoncelltypeandHIVstrain).RecognizesandinducesstructuralchangesinHIV-1envelopeproteingp120,analogoustoCD4binding.InhibitsHIV-1cellentryinCXCR4andCCR5expressingcelllines,byblockingvirus-cellandcell-cellfusion.
M.Wt | 337.84 |
Formula | C17H24ClN3O2 |
Storage | Storeat+4°C |
Purity | ≥98%(HPLC) |
CASNumber | 333353-44-9 |
PubChemID | 1570601 |
InChIKey | ZKXLQCIOURANAD-UHFFFAOYSA-N |
Smiles | CC1(CC(NC(C(NC2=CC=C(C=C2)Cl)=O)=O)CC(C)(N1)C)C |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 33.78 | 100 | |
ethanol | 6.76 | 20 |
Thefollowingdataisbasedontheproductmolecularweight337.84.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.96mL | 14.8mL | 29.6mL |
5mM | 0.59mL | 2.96mL | 5.92mL |
10mM | 0.3mL | 1.48mL | 2.96mL |
50mM | 0.06mL | 0.3mL | 0.59mL |