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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/Mitoxantrone dihydrochloride/4250/50/50 mg
产品编号:4250/50
市  场 价:¥2180.00
场      地:美国(厂家直采)
产品分类: 蛋白类>>其它酶>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$109.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/Mitoxantrone dihydrochloride/4250/50/50 mg
商品介绍
Description:TopoisomeraseIIinhibitor;immunosuppressiveandantineoplasticagent
ChemicalName:1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedionedihydrochloride
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

TypeIIDNAtopoisomeraseinhibitor.DisruptsDNAsynthesisandrepairandinducesdamagebyDNAcross-linking.AlsoinhibitsPIM1kinase(IC50=51nM).Immunomodulatory,antineoplasticandchemotherapeuticagent.AlsoUSP11inhibitor(IC50=3.15μM).Inducescelldeathofpancreaticcancercelllinesexpressingwild-typeBRCA2.

CompoundLibraries

MitoxantronedihydrochlorideisalsoofferedaspartoftheTocriscreenEpigeneticsToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt517.4
FormulaC22H28N4O6.2HCl
StorageDesiccateatRT
Purity≥98%(HPLC)
CASNumber70476-82-3
PubChemID51082
InChIKeyZAHQPTJLOCWVPG-UHFFFAOYSA-N
SmilesO=C2C3=C(C(O)=CC=C3O)C(C1=C(NCCNCCO)C=CC(NCCNCCO)=C12)=O.Cl.Cl

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO38.875
water2.595

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight517.4.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM1.93mL9.66mL19.33mL
5mM0.39mL1.93mL3.87mL
10mM0.19mL0.97mL1.93mL
50mM0.04mL0.19mL0.39mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet