Tetracyclineantibiotic.Displaysneuroprotective,antiapoptotic,anti-inflammatoryandantimicrobialeffects.Actsasamatrixmetalloproteinase(MMP)inhibitor;attenuatesdiseaseseverityinmousemodelsofmultiplesclerosis.Orallyactiveandbrainpenetrant.Allowsformationofextendedpluripotentstem(EPS)cellsincombinationwithCHIR99021(Cat.No.4423),(S)-(+)-Dimethindenemaleate(Cat.No.1425)andhumanleukemiainhibitoryfactor.
M.Wt | 493.94 |
Formula | C23H27N3O7.HCl |
Storage | Desiccateat+4°C |
Purity | ≥98%(HPLC) |
CASNumber | 13614-98-7 |
PubChemID | 54685925 |
InChIKey | WTJXVDPDEQKTCV-VQAITOIOSA-N |
Smiles | NC(C4=C(O)[C@@H](N(C)C)[C@@]3([H])[C@](C4=O)(O)C(O)=C2C(C1=C(O)C=CC(N(C)C)=C1C[C@]([H])2C3)=O)=O.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 49.39 | 100 | |
water | 12.35 | 25 |
Thefollowingdataisbasedontheproductmolecularweight493.94.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.02mL | 10.12mL | 20.25mL |
5mM | 0.4mL | 2.02mL | 4.05mL |
10mM | 0.2mL | 1.01mL | 2.02mL |
50mM | 0.04mL | 0.2mL | 0.4mL |