CytochromeP450inhibitor.Blocksglucocorticoidsynthesisviainhibitionofsteroid11-βhydroxylase(CYP11B1)activity(IC50=7.83μM).AlsoinhibitsCYP3A4andcytochromeP450-mediatedω/ω-1hydroxylaseactivity.
MetyraponeisalsoofferedaspartoftheTocriscreenPlusandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 226.27 |
Formula | C14H14N2O |
Storage | Storeat+4°C |
Purity | ≥99%(HPLC) |
CASNumber | 54-36-4 |
PubChemID | 4174 |
InChIKey | FJLBFSROUSIWMA-UHFFFAOYSA-N |
Smiles | O=C(C2=CN=CC=C2)C(C)(C)C1=CC=CN=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 22.63 | 100 | |
ethanol | 22.63 | 100 | |
water | 22.63 | 100 |
Thefollowingdataisbasedontheproductmolecularweight226.27.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 4.42mL | 22.1mL | 44.19mL |
5mM | 0.88mL | 4.42mL | 8.84mL |
10mM | 0.44mL | 2.21mL | 4.42mL |
50mM | 0.09mL | 0.44mL | 0.88mL |