Glucocorticoidreceptor(GR)agonist.Displaysanti-inflammatoryandantioxidantproperties.Attenuatesapoptosisinoligodendrocytesafterinjurystimuli.UpregulatesexpressionofBcl-xLviadirectbindingoftheGR/STAT5complex.Neuroprotective.
SoldforresearchpurposesunderagreementfromPfizerInc.
MethylprednisoloneisalsoofferedaspartoftheTocriscreenPlusandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 374.47 |
Formula | C22H30O5 |
Storage | Storeat+4°C |
Purity | ≥99%(HPLC) |
CASNumber | 83-43-2 |
PubChemID | 6741 |
InChIKey | VHRSUDSXCMQTMA-PJHHCJLFSA-N |
Smiles | O=C1C=C[C@@]2(C)C([C@@H](C)C[C@]3([H])[C@@]([H])2[C@@H](O)C[C@@]4(C)[C@]([H])3CC[C@](C(CO)=O)4O)=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 37.45 | 100 |
Thefollowingdataisbasedontheproductmolecularweight374.47.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.67mL | 13.35mL | 26.7mL |
5mM | 0.53mL | 2.67mL | 5.34mL |
10mM | 0.27mL | 1.34mL | 2.67mL |
50mM | 0.05mL | 0.27mL | 0.53mL |