Apoptotic,antiproliferativeandantiangiogenicagent,invitroandinvivo;actsviaanestrogenreceptor-independentmechanism.Inducesp53-inducedapoptosisviatwopathways:activationofp38andNF-κB;andactivationofJNKandAP-1leADIngtoBcl-2phosphorylation.Alsoupregulatesdeathreceptor5andbindstotubulin,inhibitingitsassembly.
2-MethoxyestradiolisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 302.41 |
Formula | C19H26O3 |
Storage | StoreatRT |
Purity | ≥99%(HPLC) |
CASNumber | 362-07-2 |
PubChemID | 66414 |
InChIKey | CQOQDQWUFQDJMK-SSTWWWIQSA-N |
Smiles | OC1=C(OC)C=C2C(CC[C@]3([H])[C@@]([H])2CC[C@@]4(C)[C@]([H])3CC[C@@H]4O)=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 15.12 | 50 |
Thefollowingdataisbasedontheproductmolecularweight302.41.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 3.31mL | 16.53mL | 33.07mL |
5mM | 0.66mL | 3.31mL | 6.61mL |
10mM | 0.33mL | 1.65mL | 3.31mL |
50mM | 0.07mL | 0.33mL | 0.66mL |