Mcl-1inhibitor;disruptsMcl-1-BiminteractionandinducesMcl-1proteasomaldegradation.ExhibitsnoeffectonBcl-XL-Biminteraction.SelectivelyinducesapoptosisinMcl-1-dependentK562leukemiacells.SensitizesK562andRajicellstoABT-737-inducedapoptosis.
| M.Wt | 510.15 |
| Formula | C22H12Cl4N2O4 |
| Storage | Storeat-20°C |
| Purity | ≥97%(HPLC) |
| CASNumber | 1227962-62-0 |
| PubChemID | 24797083 |
| InChIKey | QYPJBTMRYKRTFG-UHFFFAOYSA-N |
| Smiles | ClC1=C(Cl)C(N2C(C(C4=C(O)C=CC=C4)=O)=CC(Cl)=C2Cl)=C(C(C3=C(O)C=CC=C3)=O)N1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 51.01 | 100 | |
| ethanol | 25.51 | 50 |
Thefollowingdataisbasedontheproductmolecularweight510.15.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.96mL | 9.8mL | 19.6mL |
| 5mM | 0.39mL | 1.96mL | 3.92mL |
| 10mM | 0.2mL | 0.98mL | 1.96mL |
| 50mM | 0.04mL | 0.2mL | 0.39mL |



