Mcl-1inhibitor;disruptsMcl-1-BiminteractionandinducesMcl-1proteasomaldegradation.ExhibitsnoeffectonBcl-XL-Biminteraction.SelectivelyinducesapoptosisinMcl-1-dependentK562leukemiacells.SensitizesK562andRajicellstoABT-737-inducedapoptosis.
M.Wt | 510.15 |
Formula | C22H12Cl4N2O4 |
Storage | Storeat-20°C |
Purity | ≥97%(HPLC) |
CASNumber | 1227962-62-0 |
PubChemID | 24797083 |
InChIKey | QYPJBTMRYKRTFG-UHFFFAOYSA-N |
Smiles | ClC1=C(Cl)C(N2C(C(C4=C(O)C=CC=C4)=O)=CC(Cl)=C2Cl)=C(C(C3=C(O)C=CC=C3)=O)N1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 51.01 | 100 | |
ethanol | 25.51 | 50 |
Thefollowingdataisbasedontheproductmolecularweight510.15.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 1.96mL | 9.8mL | 19.6mL |
5mM | 0.39mL | 1.96mL | 3.92mL |
10mM | 0.2mL | 0.98mL | 1.96mL |
50mM | 0.04mL | 0.2mL | 0.39mL |