AnsamycinantibioticcompoundthatinhibitsHsp90activity(IC50=2μM)bybindingtotheATP-bindingsite.Exhibitsantitumorandcytocidalactivities(IC50~0.4μM)bycausingdegradationofkeyoncogenicclientproteinssuchasErbB2andcRaf1.Displayshigheraffinityandpotencythangeldanamycin(Cat.No.1368).
M.Wt | 558.67 |
Formula | C30H42N2O8 |
Storage | Desiccateat-20°C |
CASNumber | 73341-72-7 |
PubChemID | 6436263 |
InChIKey | PLTGBUPHJAKFMA-HXUNTIRESA-N |
Smiles | O=C1C=C([C@H](OC)[C@@H](C)C[C@H](OC)[C@H](OC)[C@@H](C)/C=C(C)/[C@H](OC(N)=O)[C@@H](C)/C=C/C=C(C)/C2=O)C(C(N2)=C1)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solubility | SolubleinDMSO |
Thefollowingdataisbasedontheproductmolecularweight558.67.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 1.79mL | 8.95mL | 17.9mL |
5mM | 0.36mL | 1.79mL | 3.58mL |
10mM | 0.18mL | 0.89mL | 1.79mL |
50mM | 0.04mL | 0.18mL | 0.36mL |