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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/Macbecin I/3061/1/1 mg
产品编号:3061/1
市  场 价:¥5380.00
场      地:美国(厂家直采)
产品分类: 蛋白类>天然蛋白>白蛋白>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$269.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/Macbecin I/3061/1/1 mg
商品介绍
Description:Hsp90inhibitor
ChemicalName:(15R)-6,17-Didemethoxy-15-methoxy-6-methyl-11-O-methyl-geldanamycin
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

AnsamycinantibioticcompoundthatinhibitsHsp90activity(IC50=2μM)bybindingtotheATP-bindingsite.Exhibitsantitumorandcytocidalactivities(IC50~0.4μM)bycausingdegradationofkeyoncogenicclientproteinssuchasErbB2andcRaf1.Displayshigheraffinityandpotencythangeldanamycin(Cat.No.1368).

TechnicalData

M.Wt558.67
FormulaC30H42N2O8
StorageDesiccateat-20°C
CASNumber73341-72-7
PubChemID6436263
InChIKeyPLTGBUPHJAKFMA-HXUNTIRESA-N
SmilesO=C1C=C([C@H](OC)[C@@H](C)C[C@H](OC)[C@H](OC)[C@@H](C)/C=C(C)/[C@H](OC(N)=O)[C@@H](C)/C=C/C=C(C)/C2=O)C(C(N2)=C1)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolubilitySolubleinDMSO

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight558.67.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM1.79mL8.95mL17.9mL
5mM0.36mL1.79mL3.58mL
10mM0.18mL0.89mL1.79mL
50mM0.04mL0.18mL0.36mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet