AnsamycinantibioticcompoundthatinhibitsHsp90activity(IC50=2μM)bybindingtotheATP-bindingsite.Exhibitsantitumorandcytocidalactivities(IC50~0.4μM)bycausingdegradationofkeyoncogenicclientproteinssuchasErbB2andcRaf1.Displayshigheraffinityandpotencythangeldanamycin(Cat.No.1368).
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Thefollowingdataisbasedontheproductmolecularweight558.67.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.