Potent17β-hydroxysteroiddehydrogenasetype5inhibitor(IC50=11-49nM).Suppressesandrostenedione-dependentprotein-specificantigen(PSA)productionandcellproliferationinLNCaPcellsinvitro.Orallybioavailable.
| M.Wt | 330.42 |
| Formula | C19H26N2O3 |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1126084-37-4 |
| PubChemID | 25210792 |
| InChIKey | OXSCPDKUZWPWFR-UHFFFAOYSA-N |
| Smiles | O=C(N1CCC(CC1)CC(C)(O)C)C2=CC3=CC(OC)=CC=C3N2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 33.04 | 100 | |
| ethanol | 33.04 | 100 |
Thefollowingdataisbasedontheproductmolecularweight330.42.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.03mL | 15.13mL | 30.26mL |
| 5mM | 0.61mL | 3.03mL | 6.05mL |
| 10mM | 0.3mL | 1.51mL | 3.03mL |
| 50mM | 0.06mL | 0.3mL | 0.61mL |



