Smoothened(Smo)receptorantagonist(IC50=0.5μMinHEK293cellstransientlyexpressingmouseSmo).InhibitsShhN-inducedGliluciferasereporteractivityinShh-light2cells(IC50=2.5μM);actsasaninverseagonistduringnontranscriptionalHedgehogpathwayactivation(IC50=2.5μMinHEK293cells).
| M.Wt | 465.52 |
| Formula | C24H23N3O5S |
| Storage | Storeat+4°C |
| Purity | ≥98% |
| CASNumber | 330829-30-6 |
| PubChemID | 1139102 |
| InChIKey | KVQVEZQDNHMQJV-UHFFFAOYSA-N |
| Smiles | O=C(NC(NC2=CC(NC(C3=CC=CC=C3)=O)=CC=C2)=S)C1=CC(OC)=C(OC)C(OC)=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 46.55 | 100 |
Thefollowingdataisbasedontheproductmolecularweight465.52.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.15mL | 10.74mL | 21.48mL |
| 5mM | 0.43mL | 2.15mL | 4.3mL |
| 10mM | 0.21mL | 1.07mL | 2.15mL |
| 50mM | 0.04mL | 0.21mL | 0.43mL |



