Smoothened(Smo)receptorantagonist(IC50=0.5μMinHEK293cellstransientlyexpressingmouseSmo).InhibitsShhN-inducedGliluciferasereporteractivityinShh-light2cells(IC50=2.5μM);actsasaninverseagonistduringnontranscriptionalHedgehogpathwayactivation(IC50=2.5μMinHEK293cells).
M.Wt | 465.52 |
Formula | C24H23N3O5S |
Storage | Storeat+4°C |
Purity | ≥98% |
CASNumber | 330829-30-6 |
PubChemID | 1139102 |
InChIKey | KVQVEZQDNHMQJV-UHFFFAOYSA-N |
Smiles | O=C(NC(NC2=CC(NC(C3=CC=CC=C3)=O)=CC=C2)=S)C1=CC(OC)=C(OC)C(OC)=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 46.55 | 100 |
Thefollowingdataisbasedontheproductmolecularweight465.52.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.15mL | 10.74mL | 21.48mL |
5mM | 0.43mL | 2.15mL | 4.3mL |
10mM | 0.21mL | 1.07mL | 2.15mL |
50mM | 0.04mL | 0.21mL | 0.43mL |