Potent,synthetic,cytotoxicanalogofdolastatin10(Cat.No.3375).SuppressestumorcellviABIlityinvitro(GIC50valuesare0.22,0.49and0.54nMinBT474,MDA-MB-361-DYT2andN87cells,respectively).MMAEderivativeshavebeenshowntoinduceregressionofestablishedtumorxenograftswhenconjugatedtotumortargetingantibodiesviaaprotease-cleavablelinker.
M.Wt | 717.98 |
Formula | C39H67N5O7 |
Storage | Storeat-20°C |
Purity | ≥98%(HPLC) |
CASNumber | 474645-27-7 |
PubChemID | 11542188 |
InChIKey | DASWEROEPLKSEI-UIJRFTGLSA-N |
Smiles | O=C(C[C@@H](OC)[C@@H](N(C)[C@@]([C@H](C(C)C)NC([C@H](C(C)C)NC)=O)=O)[C@@H](C)CC)N1[C@@]([C@@H]([C@H](C(N[C@@H]([C@@H](O)[C@]2=CC=CC=C2)C)=O)C)OC)([H])CCC1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 71.8 | 100 |
Thefollowingdataisbasedontheproductmolecularweight717.98.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 1.39mL | 6.96mL | 13.93mL |
5mM | 0.28mL | 1.39mL | 2.79mL |
10mM | 0.14mL | 0.7mL | 1.39mL |
50mM | 0.03mL | 0.14mL | 0.28mL |