请使用支持JavaScript的浏览器!
主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/MMAE/5683/1/1 mg
产品编号:5683/1
市  场 价:¥2580.00
场      地:美国(厂家直采)
产品分类: 生化试剂>其他>其他试剂>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$129.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/MMAE/5683/1/1 mg
商品介绍
Description:Potentdolastatin10analog;antitumor
ChemicalName:N-Methyl-L-valyl-N-[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]amino]-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl]-2-methoxy-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-L-valinamide
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potent,synthetic,cytotoxicanalogofdolastatin10(Cat.No.3375).SuppressestumorcellviABIlityinvitro(GIC50valuesare0.22,0.49and0.54nMinBT474,MDA-MB-361-DYT2andN87cells,respectively).MMAEderivativeshavebeenshowntoinduceregressionofestablishedtumorxenograftswhenconjugatedtotumortargetingantibodiesviaaprotease-cleavablelinker.

TechnicalData

M.Wt717.98
FormulaC39H67N5O7
StorageStoreat-20°C
Purity≥98%(HPLC)
CASNumber474645-27-7
PubChemID11542188
InChIKeyDASWEROEPLKSEI-UIJRFTGLSA-N
SmilesO=C(C[C@@H](OC)[C@@H](N(C)[C@@]([C@H](C(C)C)NC([C@H](C(C)C)NC)=O)=O)[C@@H](C)CC)N1[C@@]([C@@H]([C@H](C(N[C@@H]([C@@H](O)[C@]2=CC=CC=C2)C)=O)C)OC)([H])CCC1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO71.8100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight717.98.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM1.39mL6.96mL13.93mL
5mM0.28mL1.39mL2.79mL
10mM0.14mL0.7mL1.39mL
50mM0.03mL0.14mL0.28mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet