InhibitsMcl1-BIMinteraction.InhibitsviABIlityofMcl1-dependenttumorcelllines.InducescelldeathanddecreasedspheroidformationinHer2positivebreastcancercells.
M.Wt | 415.45 |
Formula | C23H24F3N3O |
Storage | Storeat-20°C |
Purity | ≥99%(HPLC) |
CASNumber | 315698-17-0 |
PubChemID | 3384730 |
InChIKey | NGAPBLRRJSKIRT-UHFFFAOYSA-N |
Smiles | CCN(CC1)CCN1C(C2=CC=C(C(F)(F)F)C=C2)C3=C(O)C4=NC=CC=C4C=C3 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 20.77 | 50 | |
ethanol | 20.77 | 50 |
Thefollowingdataisbasedontheproductmolecularweight415.45.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.41mL | 12.04mL | 24.07mL |
5mM | 0.48mL | 2.41mL | 4.81mL |
10mM | 0.24mL | 1.2mL | 2.41mL |
50mM | 0.05mL | 0.24mL | 0.48mL |