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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/ML 228/4565/50/50 mg
产品编号:4565/50
市  场 价:¥17580.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$879.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/ML 228/4565/50/50 mg
商品介绍
Description:HIFpathwayactivator
ChemicalName:N-([1,1'Biphenyl]-4-ylmethyl)-6-phenyl-3-(2-pyridinyl)-1,2,4-triazin-5-amine
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

HIFpathwayactivator(EC50valuesare1.23and1.4μMforHREgenereporterassayandHIF-1αnucleartranslocationassayrespectively);actsviachelationofiron,independentlyofPHD.Alsoexhibits>80%inhibitionofthehumanA3receptor,dopaminetransporter,μreceptor,hERGand5-HT2Breceptor,andratsodiumchannelsite2,ataconcentrationof10μM.

CompoundLibraries

ML228isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt415.49
FormulaC27H21N5
StorageStoreat-20°C
Purity≥98%(HPLC)
CASNumber1357171-62-0
PubChemID46742353
InChIKeyQNRODODTMXCRKU-UHFFFAOYSA-N
SmilesC1(C2=NC(NCC4=CC=C(C5=CC=CC=C5)C=C4)=C(C3=CC=CC=C3)N=N2)=NC=CC=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO41.55100
ethanol8.3120

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight415.49.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.41mL12.03mL24.07mL
5mM0.48mL2.41mL4.81mL
10mM0.24mL1.2mL2.41mL
50mM0.05mL0.24mL0.48mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet