Selectiveliverreceptorhomolog1(LRH1,NR5A2)inverseagonist(IC50=320nMandmaximumefficacyof64%repression).Exhibits>31-foldselectivityoverSF1.
ML179isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
| M.Wt | 422.44 |
| Formula | C21H25F3N4O2 |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| PubChemID | 45100448 |
| InChIKey | MFABFKUNLDYKGH-UHFFFAOYSA-N |
| Smiles | O=C(C=C(N3CCN(C4=CC=CC(C(F)(F)F)=C4)CC3)NC2=O)N2C1CCCCC1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 21.12 | 50 |
Thefollowingdataisbasedontheproductmolecularweight422.44.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.37mL | 11.84mL | 23.67mL |
| 5mM | 0.47mL | 2.37mL | 4.73mL |
| 10mM | 0.24mL | 1.18mL | 2.37mL |
| 50mM | 0.05mL | 0.24mL | 0.47mL |



