Occupiesmortalin-2(mot-2),amemberoftheHsp70family,atitsp53bindingsiteandenablesp53translocationtothenucleus.Selectivelycytotoxic;causesgrowtharrestofcancercellsinculture.Alsoinhibitstelomeraseactivityandcross-linksF-actin.
MKT077isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 432 |
Formula | C21H22ClN3OS2 |
Storage | Storeat+4°C |
Purity | ≥98%(HPLC) |
CASNumber | 147366-41-4 |
PubChemID | 3037933 |
InChIKey | VSKYOTRJSLYFHX-UXJRWBAGSA-M |
Smiles | CN(C1=CC=CC=C1S2)/C2=C4/C(N(CC)/C(S4)=CC3=CC=CC=[N+]3CC)=O.[Cl-] |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 21.6 | 50 | |
water | 21.6 | 50 |
Thefollowingdataisbasedontheproductmolecularweight432.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.31mL | 11.57mL | 23.15mL |
5mM | 0.46mL | 2.31mL | 4.63mL |
10mM | 0.23mL | 1.16mL | 2.31mL |
50mM | 0.05mL | 0.23mL | 0.46mL |