PotentCysLT1(LTD4)leukotrienereceptorinverseagonist(EC50=1.3nM).AntagonizesLTD4-inducedcontractionsofguineapigtracheaandileum(pA2valuesare9.4and10.5respectively).Alsoinhibitorofmultidrugresistanceprotein-1(MRP1)mediatedtransport;invitroaugmentstheeffectsofcytotoxicagentsonmalignantcells.
M.Wt | 515.09 |
Formula | C26H27ClN2O3S2 |
Storage | Storeat-20°C |
CASNumber | 115104-28-4 |
PubChemID | 5281888 |
InChIKey | AXUZQJFHDNNPFG-UXBLZVDNSA-N |
Smiles | ClC1=CC=C(C=CC(/C=C/C3=CC(C(SCCC(O)=O)SCCC(N(C)C)=O)=CC=C3)=N2)C2=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 51.51 | 100 |
Thefollowingdataisbasedontheproductmolecularweight515.09.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 1.94mL | 9.71mL | 19.41mL |
5mM | 0.39mL | 1.94mL | 3.88mL |
10mM | 0.19mL | 0.97mL | 1.94mL |
50mM | 0.04mL | 0.19mL | 0.39mL |