InhibitorofMcl-1;selectivelytargetstheBH3-bindingpocket.Inducescaspase-3/7activationandcelldeathinMcl-1-dependentleukemiacells.AlsoblocksMcl-1-mediatedsuppressionoftBID-inducedBaxactivationinvitro.
M.Wt | 347.43 |
Formula | C17H21N3O3S |
Storage | Storeat+4°C |
PubChemID | 10205 |
InChIKey | VCMMXZQDRFWYSE-UHFFFAOYSA-N |
Smiles | CC2=CS/C(N2/N=C/C3=CC=C(O)C(O)=C3O)=NC1CCCCC1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 34.74 | 100 | |
ethanol | 6.95 | 20 |
Thefollowingdataisbasedontheproductmolecularweight347.43.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.88mL | 14.39mL | 28.78mL |
5mM | 0.58mL | 2.88mL | 5.76mL |
10mM | 0.29mL | 1.44mL | 2.88mL |
50mM | 0.06mL | 0.29mL | 0.58mL |