InhibitorofMcl-1;selectivelytargetstheBH3-bindingpocket.Inducescaspase-3/7activationandcelldeathinMcl-1-dependentleukemiacells.AlsoblocksMcl-1-mediatedsuppressionoftBID-inducedBaxactivationinvitro.
| M.Wt | 347.43 |
| Formula | C17H21N3O3S |
| Storage | Storeat+4°C |
| PubChemID | 10205 |
| InChIKey | VCMMXZQDRFWYSE-UHFFFAOYSA-N |
| Smiles | CC2=CS/C(N2/N=C/C3=CC=C(O)C(O)=C3O)=NC1CCCCC1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 34.74 | 100 | |
| ethanol | 6.95 | 20 |
Thefollowingdataisbasedontheproductmolecularweight347.43.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.88mL | 14.39mL | 28.78mL |
| 5mM | 0.58mL | 2.88mL | 5.76mL |
| 10mM | 0.29mL | 1.44mL | 2.88mL |
| 50mM | 0.06mL | 0.29mL | 0.58mL |



