Histonedeacetylaseinhibitor(IC50=100nM).InducesterminalcelldifferentiationandcausesanincreaseinhyperacetylatedhistoneH4.Antiproliferativeagent;suppressesthegrowthofhumanendometrialandovariancancercellsbyinducingcellcyclearrestandapoptosis.
M344isalsoofferedaspartoftheTocriscreenPlusandTocriscreenEpigeneticsToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 307.39 |
Formula | C16H25N3O3 |
Storage | StoreatRT |
Purity | ≥98%(HPLC) |
CASNumber | 251456-60-7 |
PubChemID | 3994 |
InChIKey | MXWDSZWTBOCWBK-UHFFFAOYSA-N |
Smiles | O=C(NCCCCCCC(NO)=O)C1=CC=C(N(C)C)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 30.74 | 100 | |
ethanol | 6.15 | 20 |
Thefollowingdataisbasedontheproductmolecularweight307.39.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 3.25mL | 16.27mL | 32.53mL |
5mM | 0.65mL | 3.25mL | 6.51mL |
10mM | 0.33mL | 1.63mL | 3.25mL |
50mM | 0.07mL | 0.33mL | 0.65mL |