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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/M 25/4917/10/10 mg
产品编号:4917/10
市  场 价:¥3980.00
场      地:美国(厂家直采)
产品分类: 生化试剂>生物分子>受体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$199.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/M 25/4917/10/10 mg
商品介绍
Description:PotentSmoothened(Smo)receptorantagoNIST
ChemicalName:N-[[1-(2-Methoxyphenyl)-1H-indazol-5-yl]methyl]-2-propylpentanamide
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentSmoothened(Smo)receptorantagonist(IC50=5nM).InhibitstheHedgehogsignalingpathway.InhibitsShhinducedGliluciferasereporteractivityinShh-light2cells(IC50=5nM).AntagonizesGSA-10andSAG-mediateddifferentiationoftheC3H10T1/2cellline(IC50valuesare69and115nM,respectively).

CompoundLibraries

M25isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt379.5
FormulaC23H29N3O2
StorageStoreat+4°C
Purity≥98%(HPLC)
PubChemID44250034
InChIKeyWATNXVHKRRTUFK-UHFFFAOYSA-N
SmilesO=C(C(CCC)CCC)NCC1=CC=C(N(C3=CC=CC=C3OC)N=C2)C2=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO37.95100
ethanol37.95100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight379.5.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.64mL13.18mL26.35mL
5mM0.53mL2.64mL5.27mL
10mM0.26mL1.32mL2.64mL
50mM0.05mL0.26mL0.53mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet