RNAbindingproteinLin28inhibitor(IC50=8μM).BlocksbindingofLin28tolet-7pre-microRNA.InhibitsstemnessandinducesdifferentiationofmurineESCs.Inhibitsgrowthoftumorcelllinesandtumor-sphereformationinvitro.Alsobromodomaininhibitor.
| M.Wt | 281.31 |
| Formula | C15H15N5O |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 108825-65-6 |
| PubChemID | 2737312 |
| InChIKey | WPAQLESUVYGUJZ-UHFFFAOYSA-N |
| Smiles | CN(C1=CC=CC(C2=NN3C(C)=NN=C3C=C2)=C1)C(C)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 28.13 | 100 | |
| ethanol | 28.13 | 100 |
Thefollowingdataisbasedontheproductmolecularweight281.31.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.55mL | 17.77mL | 35.55mL |
| 5mM | 0.71mL | 3.55mL | 7.11mL |
| 10mM | 0.36mL | 1.78mL | 3.55mL |
| 50mM | 0.07mL | 0.36mL | 0.71mL |



