AllostericactivatorofCD11b/CD18.IncreasesCD11b/CD18-dependentcelladhesiontofibrinogen(EC50=4μM).Decreasesleukocytemotilityandtransendothelialmigration;reducesinflammation.Alsoactivatescomplementreceptor3(CR3),andpromotesCR3-dependentleukocyteadhesiontofibrinogen-coatedsurfaces.
M.Wt | 421.49 |
Formula | C22H15NO4S2 |
Storage | Storeat+4°C |
Purity | ≥98%(HPLC) |
CASNumber | 344897-95-6 |
PubChemID | 5342077 |
InChIKey | AEZGRQSLKVNPCI-UNOMPAQXSA-N |
Smiles | S=C(N(CC3=CC=CC=C3)C2=O)S/C2=CC1=CC=C(C4=CC=C(C(O)=O)C=C4)O1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 4.21 | 10mMwithgentlewarming |
Thefollowingdataisbasedontheproductmolecularweight421.49.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.37mL | 11.86mL | 23.73mL |
5mM | 0.47mL | 2.37mL | 4.75mL |
10mM | 0.24mL | 1.19mL | 2.37mL |
50mM | 0.05mL | 0.24mL | 0.47mL |