Potent,reversiblenon-steroidalaromataseinhibitor(IC50=11.5nM).Displaysantitumoreffectsinseveralanimalmodels.Suppressestheendogenousaromatase-inducedproliferationofMCF-7cells.
LetrozoleisalsoofferedaspartoftheTocriscreenPlusandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 285.3 |
Formula | C17H11N5 |
Storage | Storeat+4°C |
Purity | ≥99%(HPLC) |
CASNumber | 112809-51-5 |
PubChemID | 3902 |
InChIKey | HPJKCIUCZWXJDR-UHFFFAOYSA-N |
Smiles | N#CC(C=C2)=CC=C2C(N3N=CN=C3)C1=CC=C(C#N)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 28.53 | 100 |
Thefollowingdataisbasedontheproductmolecularweight285.3.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 3.51mL | 17.53mL | 35.05mL |
5mM | 0.7mL | 3.51mL | 7.01mL |
10mM | 0.35mL | 1.75mL | 3.51mL |
50mM | 0.07mL | 0.35mL | 0.7mL |