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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/Leptomycin B/1987/5U/5 ug
产品编号:1987/5U
市  场 价:¥6580.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$329.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/Leptomycin B/1987/5U/5 ug
商品介绍
Description:Inhibitsnuclearexportofproteins;antitumor
AlternativeNames:CI940,LMB
ChemicalName:(2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-19-[(2S,3S)-3,6-Dihydro-3-methyl-6-oxo-2H-pyran-2-yl]-17-ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-8-oxo-2,10,12,16,18-nonadecapentaenoicacid
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Antifungalantibioticthatisaninhibitorofthenuclearexportofproteins;actsbybindingdirectlytoandinhibitingCRM1/exportin-1.InhibitsthenuclearexportoftheHIVregulatoryproteinRevandstABIlizesp53.Antitumorinvitroandinvivo.

TechnicalData

M.Wt540.74
FormulaC33H48O6
StorageDesiccateat-20°C
CASNumber87081-35-4
PubChemID57459335
InChIKeyYACHGFWEQXFSBS-RJXCBBHPSA-N
SmilesCCC(C=C[C@@H]1OC(=O)C=C[C@@H]1C)=C/[C@H](C)CC=CC(C)=C[C@@H](C)C(=O)[C@@H](C)[C@H](O)[C@@H](C)CC(C)=CC(O)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolubilitySolubleinethanol(suppliedpre-dissolvedinanhydrousethanol,27µg/ml)

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight540.74.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM1.85mL9.25mL18.49mL
5mM0.37mL1.85mL3.7mL
10mM0.18mL0.92mL1.85mL
50mM0.04mL0.18mL0.37mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet