Selective,competitiveantagonistofBLT2receptors(IC50valuesare~1and>10μMathumanrecombinantBLT2andBLT1receptorsrespectively).InhibitsLTB4-inducedcontractionoflungparenchyma(pA2=7.2),andreducesLTB4-mediatedairwayobstructioninguineapigsfollowingi.v.andoraladministration. .
LY255283isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
| M.Wt | 360.46 |
| Formula | C19H28N4O3 |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 117690-79-6 |
| PubChemID | 122023 |
| InChIKey | WCGXJPFHTHQNJL-UHFFFAOYSA-N |
| Smiles | CCC1=C(OCCCCCC(C)(C)C2=NN=NN2)C=C(O)C(=C1)C(C)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 36.05 | 100 | |
| ethanol | 9.01 | 25 |
Thefollowingdataisbasedontheproductmolecularweight360.46.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.77mL | 13.87mL | 27.74mL |
| 5mM | 0.55mL | 2.77mL | 5.55mL |
| 10mM | 0.28mL | 1.39mL | 2.77mL |
| 50mM | 0.06mL | 0.28mL | 0.55mL |



