Selectiveinhibitorofcaseinkinase(CK)1δ(IC50valuesare290nM,1.3μMand2.5μMforCK1δ,εandα);displaysnoinhibitoryactivityatCK2.InhibitsCK1δ-dependentphosphorylationanddegradationofPER1protein.ShowntolengthenthecircADIanperiodinU2OScells,withminimaleffectonamplitude.
LH846isalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxII.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 316.81 |
Formula | C16H13ClN2OS |
Storage | Storeat+4°C |
Purity | ≥98%(HPLC) |
CASNumber | 639052-78-1 |
PubChemID | 851474 |
InChIKey | DYHAMRNAHTWYKY-UHFFFAOYSA-N |
Smiles | O=C(CC3=CC=CC=C3)NC(S2)=NC1=C2C=C(C)C(Cl)=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 31.68 | 100 | |
ethanol | 1.58 | 5mMwithgentlewarming |
Thefollowingdataisbasedontheproductmolecularweight316.81.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 3.16mL | 15.78mL | 31.56mL |
5mM | 0.63mL | 3.16mL | 6.31mL |
10mM | 0.32mL | 1.58mL | 3.16mL |
50mM | 0.06mL | 0.32mL | 0.63mL |