SelectiveRXRmodulator(Kivaluesare3,9and11forRXRα,RXRβandRXRγrespectively).DisplayspoorbindingaffinityforRARisoforms(Kivaluesare2746,3516and>10,000nMforRARα,RARβandRARγrespectively).BindingtoRXRresultsinselectiveactivationofRXR:PPARγ,RXR:PPARαandRXR:PPARδheterodimers.
| M.Wt | 420.53 |
| Formula | C25H34F2O3 |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 331248-11-4 |
| PubChemID | 9845057 |
| InChIKey | BHIBZAZKKARFIM-XRYBSMBUSA-N |
| Smiles | CC(C)(C)C1=CC(/C(C)=CC=CC(C)=CC(O)=O)=C(OCC(F)F)C(C(C)(C)C)=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 42.05 | 100 | |
| ethanol | 21.03 | 50 |
Thefollowingdataisbasedontheproductmolecularweight420.53.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.38mL | 11.89mL | 23.78mL |
| 5mM | 0.48mL | 2.38mL | 4.76mL |
| 10mM | 0.24mL | 1.19mL | 2.38mL |
| 50mM | 0.05mL | 0.24mL | 0.48mL |



