NovelRXR:PPARγagonist;sensitizesPPARγbyenhancingitsligandbindingactivity.AlsoactivatesRXR:RARandRXR:PPARαheterodimersincotransfectionassays.DisplaysselectivityoverotherpermissiveheterodimerssuchasRXR:LXRαandRXR:BAR/FXR.Exhibitsantidiabeticpropertiesinvivo.
| M.Wt | 396.56 |
| Formula | C26H36O3 |
| Storage | Storeat-20°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 180713-37-5 |
| PubChemID | 6442223 |
| InChIKey | HNODNXQAYXJFMQ-LQUSFLDPSA-N |
| Smiles | CC1(C)C2=C(C=C(OCCC)C(/C(C)=CC=CC(C)=CC(O)=O)=C2)C(C)(C)CC1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.66 | 100 | |
| ethanol | 19.83 | 50 |
Thefollowingdataisbasedontheproductmolecularweight396.56.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.52mL | 12.61mL | 25.22mL |
| 5mM | 0.5mL | 2.52mL | 5.04mL |
| 10mM | 0.25mL | 1.26mL | 2.52mL |
| 50mM | 0.05mL | 0.25mL | 0.5mL |



