Fluorescentligandthatbindstotheα4β1integrin(VLA-4)withhighaffinity(Kdvaluesare0.3nMand12nMforbindingtoU937cellsinthepresenceandabsenceofMn2+respectively).UsedtodetectVLA-4affinityandconformationalchanges.
M.Wt | 1368.54 |
Formula | C69H81N11O17S |
Sequence | LDVPAAK(Modifications:Leu-1N-2-[4-[[[(2-methylphenyl)amino]carbonyl]amino]phenyl]acetyl-,Lys-6N-FITCconjugate) |
Storage | Storeat-20°C |
CASNumber | 1207610-07-8 |
PubChemID | 91826076 |
InChIKey | PAAUNHNWVWSJKI-CBRXRBRLSA-N |
Smiles | CC(C)C[C@H](NC(=O)Cc1ccc(NC(=O)Nc2ccccc2C)cc1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCNC(=S)Nc1ccc(C(O)=O)c(c1)-c1c-2ccc(=O)cc-2oc2cc(O)ccc12)C(O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solubility | Solubleto1mg/mlinPBS(pH7.4) |
Thefollowingdataisbasedontheproductmolecularweight1368.54.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 0.73mL | 3.65mL | 7.31mL |
5mM | 0.15mL | 0.73mL | 1.46mL |
10mM | 0.07mL | 0.37mL | 0.73mL |
50mM | 0.01mL | 0.07mL | 0.15mL |