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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/L189/3561/10/10 mg
产品编号:3561/10
市  场 价:¥3180.00
场      地:美国(厂家直采)
产品分类: 分子类>核酸酶类>连接酶>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$159.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/L189/3561/10/10 mg
商品介绍
Description:DNAligaseI,IIIandIVinhibitor
ChemicalName:6-Amino-2,3-dihydro-5-[(phenylmethylene)amino]-2-4(1H)-pyrimidineone
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

DNAligaseI,IIIandIVinhibitor(IC50valuesare5,9and5μMrespectively)thatblocksDNAbinding(Ki=5μMforDNAligaseI).Preferentiallyinhibitsstep2oftheligationreaction,andinhibitsbaseexcisionrepair(BER)andnon-homologousendjoining(NHEJ).SpecificallysensitizescancercellstoDNAdamageandincreasesthecytotoxicityofDNA-damagingagents.

TechnicalData

M.Wt246.29
FormulaC11H10N4OS
StorageStoreat-20°C
CASNumber64232-83-3
PubChemID824710
InChIKeySAKOXVNKDMWWLF-UHFFFAOYSA-N
SmilesS=C1NC(N)=C(/N=C/C2=CC=CC=C2)C(N1)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO24.63100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight246.29.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM4.06mL20.3mL40.6mL
5mM0.81mL4.06mL8.12mL
10mM0.41mL2.03mL4.06mL
50mM0.08mL0.41mL0.81mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet