Potentandselectivebreastcancerresistanceproteinmultidrugtransporter(BCRP)inhibitor(EC90=26nM).Displays>200-foldselectivityoverP-gpandMRP-1transporters.IncreasesintracellulardrugaccumulationandreversesBCRP-mediatedmultidrugresistance.InhibitsABCB1andABCC1athigherconcentrations.Rapidlymetabolizedinratplasma.
Ko143isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 469.57 |
Formula | C26H35N3O5 |
Storage | Storeat-20°C |
Purity | ≥99%(HPLC) |
CASNumber | 461054-93-3 |
PubChemID | 10322450 |
InChIKey | NXNRAECHCJZNRF-JBACZVJFSA-N |
Smiles | O=C(N[C@H]4CCC(OC(C)(C)C)=O)[C@]3([H])CC1=C([C@H](CC(C)C)N3C4=O)NC2=C1C=CC(OC)=C2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 23.48 | 50 | |
ethanol | 46.96 | 100 |
Thefollowingdataisbasedontheproductmolecularweight469.57.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.13mL | 10.65mL | 21.3mL |
5mM | 0.43mL | 2.13mL | 4.26mL |
10mM | 0.21mL | 1.06mL | 2.13mL |
50mM | 0.04mL | 0.21mL | 0.43mL |