Potentlyinducesdifferentiationofhumanmesenchymalstemcellsintochondrocytes(EC50=100nM).Reducesdiseaseseverityinamousemodelofosteoarthritis;displaysprotectiveeffectsagainstosteoarthriticstimuliinmaturechondrocytesinvitro.
KartogeninisalsoofferedaspartoftheTocriscreenPlusandTocriscreenStemCellToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
| M.Wt | 317.34 |
| Formula | C20H15NO3 |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 4727-31-5 |
| PubChemID | 2826191 |
| InChIKey | SLUINPGXGFUMLL-UHFFFAOYSA-N |
| Smiles | O=C(NC2=CC=C(C3=CC=CC=C3)C=C2)C1=CC=CC=C1C(O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 31.73 | 100 | |
| ethanol | 15.87 | 50 |
Thefollowingdataisbasedontheproductmolecularweight317.34.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.15mL | 15.76mL | 31.51mL |
| 5mM | 0.63mL | 3.15mL | 6.3mL |
| 10mM | 0.32mL | 1.58mL | 3.15mL |
| 50mM | 0.06mL | 0.32mL | 0.63mL |



